Growth factor control of bone mass
نویسندگان
چکیده
منابع مشابه
Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation.
Basic fibroblast growth factor (FGF-2), an important modulator of cartilage and bone growth and differentiation, is expressed and regulated in osteoblastic cells. To investigate the role of FGF-2 in bone, we examined mice with a disruption of the Fgf2 gene. Measurement of trabecular bone architecture of the femoral metaphysis of Fgf2(+/+) and Fgf2(-/-) adult mice by micro-CT revealed that the p...
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15 صفحه اولEffects of fibroblast growth factor-2 on longitudinal bone growth.
In vivo, fibroblast growth factor-2 (FGF-2) inhibits longitudinal bone growth. Similarly, activating FGF receptor 3 mutations impair growth in achondroplasia and thanatophoric dysplasia. To investigate the underlying mechanisms, we chose a fetal rat metatarsal organ culture system that would maintain growth plate histological architecture. Addition of FGF-2 to the serum-free medium inhibited lo...
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2009
ISSN: 0730-2312,1097-4644
DOI: 10.1002/jcb.22322